This is the hunting setup I used at this level. You are welcome to try it for yourself but this setup may not work for everyone. Stats shown are without buffs.
This is an armor based setup. Initially I would have gone with a defense based setup because the creature has Piercing Strike and Critical Hit, but ultimately went with armor because it was easier to get the necessary armor than the necessary defense. All items except the rune were at least partially forged and crafted. I do not use potions and most of my buffs were lvl 242.